LA UDES PUBLICA
Fecha de publicación:
2020-10-01
Tipo:
Article
Identificación:
SCOPUS_ID:85091929598
eID:
2-s2.0-85091929598
Nombre de la revista:
Biodiversitas
Título del artículo:

Pharmacognostic, chemical and mucolytic activity study of malva pseudolavatera webb & berthel. And malva sylvestris l. (malvaceae) leaf extracts, grown in ecuador

Among the cultivated and/or native plant species of Ecuador, are those belonging to Malvaceae. Of these, the most traditionally used are Malva pseudolavatera Webb & Berthel. and Malva sylvestris L., which are grown and sold in indigenous markets. Various articles have been published for M. sylvestris about its chemical composition and pharmacological properties; however, M. pseudolavatera lacks references and is the most commercialized in Ecuador. Therefore, this work sets the following objective: To carry out a comparative study of the pharmacognostic, chemical and mucolytic activity of the species M. pseudolavatera and M. sylvestris. The species studied were collected in the province of Chimborazo. Extracts were obtained with different solvents: water, hexane and 80% ethanol. The aqueous extract was used to determine the mucolytic activity; the hexane and alcoholic extracts were analyzed by the coupled gas chromatography-mass spectrometry system. It was found that M. pseudolavatera has a very similar chemical composition to M. sylvestris; The presence of fatty acids, di and triterpenoids, phytosterols and abundant amino acids was detected. Both species showed an important mucolytic effect, the activity of M. pseudolavatera being higher than the highest doses tested. These studies provide scientific data that allow demonstrating the high potentiality of extracts from the leaves of two Malva species as sources of plant material for possible research and development of phytotherapeutic products with mucolytic and gastroprotective activity in correspondence with their uses in traditional Ecuadorian herbal medicine.

Autor(es) UDES:
Delgado-Hernández R.
Otros Autores:
Sarmiento-Tomalá G.M., Miranda-Martínez M., Chóez-Guaranda I.A., Gutiérrez-Gaitén Y.I., Carrillo-Lavid G.
Autor Principal:
Sarmiento-Tomalá G.M.
Áreas del conocimiento:
Animal Science and Zoology, Molecular Biology, Plant Science
Acerca de la revista donde se publicó este artículo:

Biodiversitas

Cuartil Q3
Ranking
15090
Tipo
Journal
ISSN
1412033X
eISSN
20854722
Región
Asiatic Region
País
Indonesia
Volumen
21
Rango de páginas
4755-4763
Cobertura
2014-2021
Fecha de publicación:
2020-08-05
Tipo:
Conference Paper
Número de artículo:
012005
Identificación:
SCOPUS_ID:85090786456
eID:
2-s2.0-85090786456
Nombre de la revista:
Journal of Physics: Conference Series
Título del artículo:

Post-consumption foamed polystyrene coatings for surface tension modification

Foamed polystyrene, commercially known as Icopor, occupies a very important place in the transport systems, and conservation of freight and food, but it is also one of the main polymeric pollutants, due to its low biodegradability, and low reuse. Polystyrene has in its structure aromatic and aliphatic functional groups, which have a high hydrophobicity, which makes them candidates as modifiers of permeability and surface properties, although for this purpose the implementation of solvents is also required. In the following work, polystyrene residues for domestic and food use were used to obtain coatings, which allow surface tension to be modified, on surfaces with high water permeability. For this purpose, the polymeric residue was dissolved in organic type solvents, generating a varnish, which was used to coat the study surface, from which the surface tension with respect to water was previously known by analysing the contact angle; to be compared with those obtained after coating, resulting in an increase in the contact angle, which indicates an increase in surface tension, conferred on the new surface hydrophobicity.

Autor(es) UDES:
Bustos N., Gamarra C., Ponton D., Roa M.
Autor Principal:
Bustos N.
Áreas del conocimiento:
Physics and Astronomy (all)
Acerca de la revista donde se publicó este artículo:

Journal of Physics: Conference Series

Ranking
18099
Tipo
Conference Proceeding
ISSN
17426588
eISSN
17426596
Región
Western Europe
País
United Kingdom
Volumen
1587
Cobertura
2005-2021
Fecha de publicación:
2020-08-01
Tipo:
Article
Identificación:
SCOPUS_ID:85091509079
eID:
2-s2.0-85091509079
Nombre de la revista:
Ciencia Tecnologia Agropecuaria
Título del artículo:

Estimation of the potential for bioethanol production from the residues of cacao husks in Ecuador

In this study, the theoretically obtainable bioethanol production potential is estimated from the use of cacao residues in Ecuador, through the formulation of a mathematical model of the acid hydrolysis in cellulose of cacao husks and its conversion to ethanol by fermentation. Methodologically, the study was based on official documentation on the national and provincial amount of residual biomass of this crop, and on a kinetic model adapted to the case under study. An amount of 8.28 Mml of bioethanol was obtained, whose mixture with extra gasoline, at a ratio of 5:95 v/v, results in the Ecopaís E5C gasoline. Production of 166 Mml of E5C was estimated, corresponding to 10 % of the national production for the year 2017 and 56 % of the production for the year 2014, year in which the residual biomass of cacao was estimated. The coastal region contributes with 71 % of the national bioethanol and E5C production, led by the province of Guayas, in which E5 gasoline represents 25 % of its consumption in 2017. It is concluded that this production route of bioethanol is an attractive diversification option of the current production route based on the cultivation of sugarcane, adding value to residual biomass that is currently discarded. The theoretical results constitute the basis for more detailed studies in those provinces that combine a high potential for cacao residues and increasing consumption of E5 but must be complemented with experimental research to corroborate their validity and provide elements that determine the viability of the bioethanol production route studied.

Autor(es) UDES:
Rivera F.R.P.
Otros Autores:
Avila J.M.S., Noboa J.W.D., Quezada J.P.S.
Autor Principal:
Avila J.M.S.
Áreas del conocimiento:
Agricultural and Biological Sciences (all)
Acerca de la revista donde se publicó este artículo:

Ciencia Tecnologia Agropecuaria

Cuartil Q4
Ranking
19715
Tipo
Journal
ISSN
01228706
eISSN
25005308
Región
Latin America
País
Colombia
Volumen
21
Cobertura
2016-2021
Fecha de publicación:
2020-08-01
Tipo:
Article
Número de artículo:
e00147
Identificación:
SCOPUS_ID:85083774370
eID:
2-s2.0-85083774370
Nombre de la revista:
Parasite Epidemiology and Control
Título del artículo:

Toxoplasma gondii in small ruminants in northeastern areas of Colombia: Seroprevalence and risk factors

Sheep and goats are susceptible to infections with Toxoplasma gondii and could play an important role in the transmission of the zoonotic parasite to human. We conducted a cross sectional study to estimate the seroprevalence and to assess the risk factors for T. gondii seropositivity in small ruminants under traditional husbandry systems. This study was carried out from November 2015 to April 2016 in randomly selected small ruminants (n = 1038) from 48 farms located in Colombia, in the departments of northern Cesar in the north and La Guajira in the south. An indirect ELISA was used to detect IgG antibodies to T. gondii in the animals. A standardized questionnaire was used to obtain information on putative risk factors. We conducted the association analyses by using univariable and multivariate logistic regression and report odds ratios (OR) with 95% confidence interval (C.I). The overall seroprevalence in small ruminants was 23.5% (C.I: 21–26.2%). Sheep showed a higher seroprevalence (25.1% C.I: 22.4–28.6%) than goats (18.4% C.I: 22.4–28.6%). The association analysis recognized as risk factors for T. gondii seropositivity farming pigs in addition to small ruminants (OR = 1.96 C.I: 1.414–2.743), the inexistence of manure heap (OR = 2.254 C.I: 1.480–3.433) and drinking water from locally aqueducts (OR = 1.489 C.I: 1.006–2.204). The results of the study confirmed that exposure to T. gondii is common in sheep and goats in dry Caribbean regions of Colombia.

Autor(es) UDES:
Martínez-Rodriguez L.C.
Otros Autores:
Tafur-Gómez G.A., Guzman-Barragan B.L.
Autor Principal:
Martínez-Rodriguez L.C.
Áreas del conocimiento:
Parasitology, Epidemiology, Infectious Diseases
Acerca de la revista donde se publicó este artículo:

Parasite Epidemiology and Control

Cuartil Q2
Ranking
7883
Tipo
Journal
eISSN
24056731
Región
Western Europe
País
United Kingdom
Volumen
10
Cobertura
2016-2021
Fecha de publicación:
2020-07-01
Tipo:
Article
Identificación:
SCOPUS_ID:85093110584
eID:
2-s2.0-85093110584
Nombre de la revista:
Colombia Forestal
Título del artículo:

Methodological proposal for the construction and selection of digital high-precision elevation models

Digital Elevation Models improve accuracy in terrain analysis. This work compared different interpolation methods using statistical criteria in a topographic survey of 339 points raised with a total station in the “San Juan de Lagunillas” area (Venezuela). The existence of a significant trend process with spatial autocorrelation modeled by an isotropic Gaussian semivariogram was documented. The kriging allowed to obtain residuals less than a minimum tolerable error equal to 0.1 m. The residual kriging was the best evaluated in cross validation with exclusion (absolute mean error of 0.71 m). The disjunctive kriging showed a lower error average but a wider error range and the highest mean absolute error (12.8 m). The other kriging showed mean error variance greater than 1.3 m and absolute minimum errors greater than 0.85 m. Due to the high dependence on the model specification form, graphics are recommended for a better fit.

Autor(es) UDES:
Torres H.
Otros Autores:
Andrades J., Cuesta L., Camargo C., López J., Osorio A.
Autor Principal:
Andrades J.
Áreas del conocimiento:
Forestry, Soil Science, Nature and Landscape Conservation
Acerca de la revista donde se publicó este artículo:

Colombia Forestal

Cuartil Q4
Ranking
19765
Tipo
Journal
ISSN
01200739
eISSN
2256201X
Región
Latin America
País
Colombia
Volumen
23
Rango de páginas
34-46
Cobertura
2016-2021
Fecha de publicación:
2020-07-01
Tipo:
Article
Número de artículo:
200266
Identificación:
SCOPUS_ID:85090167666
eID:
2-s2.0-85090167666
Nombre de la revista:
Royal Society Open Science
Título del artículo:

Complex ecological interactions across a focus of cutaneous leishmaniasis in Eastern Colombia: novel description of Leishmania species, hosts and phlebotomine fauna

This study aimed to analyse the patterns of diversity, blood sources and Leishmania species of phlebotomines in a focus of cutaneous leishmaniasis in Arboledas, Eastern Colombia. In total, 1729 phlebotomines were captured in two localities (62.3% Siravita and 37.7% Cinera) and five environments of Norte de Santander. We identified 18 species of phlebotomines: Pintomyia ovallesi (29.8%), Psychodopygus davisi (20.3%), Pi. spinicrassa (18.5%) and Lutzomyia gomezi (15.8%) showed the highest abundance. Species diversities were compared between Cinera (15.00) and Siravita (20.00) and among five microenvironments: forest remnants (19.49), coffee plantations (12.5), grassland (12.99), cane plantations (11.66) and citrus plantations (12.22). Leishmania DNA was detected in 5.8% (80/1380) of females, corresponding mainly to Pi. ovallesi (22/80; 27.2%), Lu. gomezi (17/80; 21.3%) and Pi. spinicrassa (11/80; 13.8%). Leishmania species were 63.1% L. braziliensis, 18.5% L. panamensis, 13.2% L. infantum and 6.1% L. amazonensis. The most frequent feeding sources were Homo sapiens (50%), Bos taurus (13.8%) and Canis lupus familiaris (10.3%). This focus of cutaneous leishmaniasis has a high diversity of Leishmania-carrying phlebotomines that feed on domestic animals. The transmission of leishmaniasis to human hosts was mainly associated with Lu. gomezi, Pi. ovallesi and L. braziliensis.

Autor(es) UDES:
Sandoval-Ramírez C.M., Martínez-Vega R.A.
Otros Autores:
Hernández C., Teherán A.A., Gutierrez-Marin R., Morales D., Hoyos-Lopez R., Araque-Mogollón A., Ramírez J.D.
Autor Principal:
Sandoval-Ramírez C.M.
Áreas del conocimiento:
Multidisciplinary
Acerca de la revista donde se publicó este artículo:

Royal Society Open Science

Cuartil Q1
Ranking
6179
Tipo
Journal
eISSN
20545703
Región
Western Europe
País
United Kingdom
Volumen
7
Cobertura
2014-2021
Fecha de publicación:
2020-07-01
Tipo:
Review
Identificación:
SCOPUS_ID:85087467894
eID:
2-s2.0-85087467894
Nombre de la revista:
American Journal of Clinical Nutrition
Título del artículo:

Association of nut intake with risk factors, cardiovascular disease, and mortality in 16 countries from 5 continents: Analysis from the Prospective Urban and Rural Epidemiology (PURE) study

Background: The association of nuts with cardiovascular disease and deaths has been investigated mostly in Europe, the USA, and East Asia, with few data available from other regions of the world or from low- and middle-income countries. Objective: To assess the association of nuts with mortality and cardiovascular disease (CVD). Methods: The Prospective Urban Rural Epidemiology study is a large multinational prospective cohort study of adults aged 35-70 y from 16 low-, middle-, and high-income countries on 5 continents. Nut intake (tree nuts and ground nuts) was measured at the baseline visit, using country-specific validated FFQs. The primary outcome was a composite of mortality or major cardiovascular event [nonfatal myocardial infarction (MI), stroke, or heart failure]. Results: We followed 124,329 participants (age = 50.7 y, SD = 10.2; 41.5% male) for a median of 9.5 y. We recorded 10,928 composite events [deaths (n = 8,662) or major cardiovascular events (n = 5,979)]. Higher nut intake (>120 g per wk compared with <30 g per mo) was associated with a lower risk of the primary composite outcome of mortality or major cardiovascular event [multivariate HR (mvHR): 0.88; 95% CI: 0.80, 0.96; P-trend = 0.0048]. Significant reductions in total (mvHR: 0.77; 95% CI: 0.69, 0.87; P-trend <0.0001), cardiovascular (mvHR: 0.72; 95% CI: 0.56, 0.92; P-trend = 0.048), and noncardiovascular mortality (mvHR: 0.82; 95% CI: 0.70, 0.96; P-trend = 0.0046) with a trend to reduced cancer mortality (mvHR: 0.81; 95% CI: 0.65, 1.00; P-trend = 0.081) were observed. No significant associations of nuts were seen with major CVD (mvHR: 0.91; 95% CI: 0.81, 1.02; P-trend = 0.14), stroke (mvHR: 0.98; 95% CI: 0.84, 1.14; P-trend = 0.76), or MI (mvHR: 0.86; 95% CI: 0.72, 1.04; P-trend = 0.29). Conclusions: Higher nut intake was associated with lower mortality risk from both cardiovascular and noncardiovascular causes in low-, middle-, and high-income countries.

Otros Autores:
De Souza R.J., Dehghan M., Mente A., Bangdiwala S.I., Ahmed S.H., Alhabib K.F., Altuntas Y., Basiak-Rasała A., Dagenais G.R., Diaz R., Amma L.I., Kelishadi R., Khatib R., Lear S.A., Lopez-Jaramillo P., Mohan V., Poirier P., Rangarajan S., Rosengren A., Ismail R., Swaminathan S., Wentzel-Viljoen E., Yeates K., Yusuf R., Teo K.K., Anand S.S., Yusuf S.
Autor Principal:
De Souza R.J.
Áreas del conocimiento:
Medicine (miscellaneous), Nutrition and Dietetics
Acerca de la revista donde se publicó este artículo:

American Journal of Clinical Nutrition

Tipo
Journal
ISSN
00029165
eISSN
19383207
Volumen
112
Rango de páginas
208-219
Fecha de publicación:
2020-07-01
Tipo:
Article
Identificación:
SCOPUS_ID:85084786013
eID:
2-s2.0-85084786013
Nombre de la revista:
Reproduction
Título del artículo:

Endometrial and decidual stromal precursors show a different decidualization capacity

Endometrial stromal cells (EnSCs) and decidual stromal cells (DSCs) originate from fibroblastic precursors located around the vessels of the human nonpregnant endometrium and the pregnant endometrium (decidua), respectively. Under the effect of ovarian or pregnancy hormones, these precursors differentiate (decidualize), changing their morphology and secreting factors that appear to be essential for the normal development of pregnancy. However, the different physiological context - that is, non-pregnancy vs pregnancy - of those precursors (preEnSCs, preDSCs) might affect their phenotype and functions. In the present study, we established preEnSC and preDSC lines and compared the antigen phenotype and responses to decidualization factors in these two types of stromal cell line. Analyses with flow cytometry showed that preEnSCs and preDSCs exhibited a similar antigen phenotype compatible with that of bone marrow mesenchymal stem/stromal cells. The response to decidualization in cultures with progesterone and cAMP was evaluated by analyzing changes in cell morphology by microscopy, prolactin and IL-15 secretion by enzyme immunoassay and the induction of apoptosis by flow cytometry. In all four analyses, preDSCs showed a significantly higher response than preEnSCs. The expression of progesterone receptor (PR), protein kinase A (PKA) and FOXO1 was studied with Western blotting. Both types of cells showed similar levels of PR and PKA, but the increase in PKA RI subunit expression in response to decidualization was again significantly greater in preDSCs. We conclude that preEnSCs and preDSCs are equivalent cells but differ in their ability to decidualize. Functional differences between them probably derive from factors in their different milieus.

Autor(es) UDES:
Blanco O.
Otros Autores:
Magaña M.J.R., Puerta J.M., Martínez-Aguilar R., Llorca T., Muñoz-Fernández R., Olivares E.G., Ruiz-Ruiz C.
Autor Principal:
Magaña M.J.R.
Áreas del conocimiento:
Embryology, Reproductive Medicine, Endocrinology, Obstetrics and Gynecology, Cell Biology
Acerca de la revista donde se publicó este artículo:

Reproduction

Tipo
Journal
ISSN
14701626
eISSN
17417899
Volumen
160
Rango de páginas
83-91
Fecha de publicación:
2020-07-01
Tipo:
Article
Identificación:
SCOPUS_ID:85068540336
eID:
2-s2.0-85068540336
Nombre de la revista:
Drying Technology
Título del artículo:

Evolution of the porous structure of cocoa beans during microwave drying

In this work, it was evaluated the morphological changes of the porous structure of the cocoa bean samples subjected to microwave drying. The use of microwaves (MWs) applied by ON-OFF on cocoa bean samples allowed to avoid both the burning and the roasting of the beans. During the MWs drying process, phenomena of breakage of cellular structure, coalescence and, pore plugging altered the average pore diameter, the pore volume, surface area, and Pore Size Distribution (PSD). When the results of sun-dried beans were compared with those of beans dried by MWs, it was concluded that the average pore diameter, the pore volume, the surface area and, PSD were also affected by the solar drying; however, the breakage of cellular structure did not occur.

Autor(es) UDES:
Rincón E.
Otros Autores:
Alean J., Chejne F., Maya J.C., Camargo-Trillos D., Ramírez S., Rojano B.
Autor Principal:
Alean J.
Áreas del conocimiento:
Chemical Engineering (all), Physical and Theoretical Chemistry
Acerca de la revista donde se publicó este artículo:

Drying Technology

Tipo
Journal
ISSN
07373937
eISSN
15322300
Volumen
38
Rango de páginas
1313-1322
Fecha de publicación:
2020-06-29
Tipo:
Conference Paper
Número de artículo:
012018
Identificación:
SCOPUS_ID:85088150983
eID:
2-s2.0-85088150983
Nombre de la revista:
IOP Conference Series: Materials Science and Engineering
Título del artículo:

A proposal for updating the Response Spectrum of San Jose de Cucuta, Colombia

An analysis of seismic signals captured in three stations of the network of accelerographs of the Colombian Geological Service (SGC, by its acronym in Spanish) was developed for the city of San Jose de Cucuta, Colombia. Earthquake Equivalent, Response Analysis (EERA) and DEGTRA4 software were used for analysis, processing and calculation of signal response spectra during the characterization and propagation modelling of the signal by profiles. For the accelerograms family, a normalization factor computed with respect to the Peak Ground Acceleration (PGA) was obtained by superposition against the typical design spectrum of the Colombian earthquake resistant code (NSR10). It was found that there is a band of frequencies above the maximum acceleration zone of the design spectrum of the current standard. This suggests a revision of the seismic threat of the city of Cucuta and the urgent need to develop the seismic microzoning, which would allow a substantial reduction of the seismic risk.

Autor(es) UDES:
Lozano C.F.
Otros Autores:
Florez C.H., Marquez J.F.
Autor Principal:
Florez C.H.
Áreas del conocimiento:
Materials Science (all), Engineering (all)
Acerca de la revista donde se publicó este artículo:

IOP Conference Series: Materials Science and Engineering

Ranking
16477
Tipo
Conference Proceeding
ISSN
17578981
eISSN
1757899X
Región
Western Europe
País
United Kingdom
Volumen
844
Cobertura
2009-2021
Fecha de publicación:
2020-06-29
Tipo:
Conference Paper
Número de artículo:
012007
Identificación:
SCOPUS_ID:85088115064
eID:
2-s2.0-85088115064
Nombre de la revista:
IOP Conference Series: Materials Science and Engineering
Título del artículo:

Scientific reasoning skills and patterns of use of Information and Communication Technologies. the case of the students of the Universidad de Santander (Valledupar, Colombia)

This research establishes the relationship that has had the development of the skills of scientific reasoning and the patterns of use of tools and resources of information and communication technology (ICT). For that, it is necessary to use Lawson Test and to have into account ICT National Standards for students that USA International Society for Technology in Education (ISTE) suggest. Also, this paper is tackled from a non-experimental design featuring a correlational - transectional range. The population consists of 2035 students from a higher education institution of the Colombian Caribbean coast. Besides, stratified random sampling is used defining, defining strata and a representative sample for academic programs. Personal survey was used to collect information. The existence of relationship between scientific reasoning skills and patterns of use of information and communication technology was confirmed.

Autor(es) UDES:
Angulo Blanquicett G.E., Vidal-Tovar C.R.
Otros Autores:
Rios-Dominguez I.C.
Autor Principal:
Angulo Blanquicett G.E.
Áreas del conocimiento:
Materials Science (all), Engineering (all)
Acerca de la revista donde se publicó este artículo:

IOP Conference Series: Materials Science and Engineering

Ranking
16477
Tipo
Conference Proceeding
ISSN
17578981
eISSN
1757899X
Región
Western Europe
País
United Kingdom
Volumen
844
Cobertura
2009-2021
Fecha de publicación:
2020-06-24
Tipo:
Article
Número de artículo:
1431
Identificación:
SCOPUS_ID:85087682335
eID:
2-s2.0-85087682335
Nombre de la revista:
Frontiers in Microbiology
Título del artículo:

Bactericidal Effect of Entomopathogenic Bacterium Pseudomonas entomophila Against Xanthomonas citri Reduces Citrus Canker Disease Severity

The bacterium Pseudomonas entomophila has been recognized as an exceptional species within the Pseudomonas genus, capable of naturally infecting and killing insects from at least three different orders. P. entomophila ingestion leads to irreversible gut damage resulting from a global blockage of translation, which impairs both immune and tissue repair systems in the insect intestine. In this study we isolated a P. entomophila bacterial strain from soil samples which displayed a strong activity against Xanthomonas citri subsp, citri (Xcc), the etiological agent of citrus canker disease. The antagonism potential of isolated bacteria against Xcc and its ability to reduce citrus canker severity was assessed both ex planta and in planta. Our findings show that pathogenicity assays in Citrus x limonia by pressure infiltration and spray with a mixture of P. entomophila and Xcc leaded to a significant reduction in the number of canker lesions in high susceptible citrus leaves, at 21 days post-infection. To the best of our knowledge this is the first report of antibacterial activity of P. entomophila against a phytopathogenic bacterium. Collective action of P. entomophila factors such as diketopiperazine production and the type 6 secretion system (T6SS) may be involved in this type of biological control of citrus canker. The results suggest that the P. entomophila strain could be a promising biocontrol agent acting directly against Xcc.

Autor(es) UDES:
Caicedo J.C.
Otros Autores:
Villamizar S., Ferro J.A., Alves L.M.C.
Autor Principal:
Villamizar S.
Áreas del conocimiento:
Microbiology, Microbiology (medical)
Acerca de la revista donde se publicó este artículo:

Frontiers in Microbiology

Cuartil Q1
Ranking
2637
Tipo
Journal
eISSN
1664302X
Región
Western Europe
País
Switzerland
Volumen
11
Cobertura
2010-2021
Fecha de publicación:
2020-06-15
Tipo:
Article
Número de artículo:
146045
Identificación:
SCOPUS_ID:85081659264
eID:
2-s2.0-85081659264
Nombre de la revista:
Applied Surface Science
Título del artículo:

Immobilization of Ib-M2 peptide on [email protected] nanostructures based on SPION nanoparticles and their antibacterial activity against Escherichia coli O157:H7

Antimicrobial peptides arise as a very promising alternative for the treatment of infections generated by pathogenic microorganisms. The Ib-M2 antimicrobial peptide turns out to be a very promising candidate for these types of applications. However, it is required to evaluate immobilization systems that give peptides greater stability and activity in order to be used in biological systems. Given the above, this paper reports the preparation of superparamagnetic iron oxide nanoparticles (SPIONs) coated with chitosan in order to immobilize the Ib-M2 antimicrobial peptide. Structural properties of SPIONs were studied by DLS, SEM, XRD, FT-IR, XPS and the magnetic properties were evaluated by vibrating-sample magnetometer technique. The antimicrobial activity of the Ib-M2/[email protected] bioconjugate obtained was evaluated against Escherichia coli O157:H7 by determining the minimum inhibitory concentration (MIC). Results show that the SPIONs obtained have particle size between 10 and 15 nm with a magnetite-type structure which was confirmed by FT-IR and XPS. Characterization of magnetic properties evidences a superparamagnetic behavior of nanoparticles obtained. MIC results showed that Ib-M2/[email protected] bioconjugate exhibit a comparable or higher activity against E. coli in comparison with the free Ib-M2 peptide. These results show that the bioconjugate obtained can be considered for use in biomedical applications.

Autor(es) UDES:
Ropero-Vega J.L., Ardila-Rosas N., Hernández I.P., Flórez-Castillo J.M.
Autor Principal:
Ropero-Vega J.L.
Áreas del conocimiento:
Chemistry (all), Condensed Matter Physics, Physics and Astronomy (all), Surfaces and Interfaces, Surfaces, Coatings and Films
Acerca de la revista donde se publicó este artículo:

Applied Surface Science

Cuartil Q1
Ranking
3275
Tipo
Journal
ISSN
01694332
Región
Western Europe
País
Netherlands
Volumen
515
Cobertura
1984-2022
Fecha de publicación:
2020-06-01
Tipo:
Article
Número de artículo:
e0008375
Identificación:
SCOPUS_ID:85087345832
eID:
2-s2.0-85087345832
Nombre de la revista:
PLoS Neglected Tropical Diseases
Título del artículo:

Etiology of acute gastroenteritis among children less than 5 years of age in bucaramanga, colombia: A case-control study

Background Acute gastroenteritis (AGE) is a major cause of morbidity and mortality in children aged less than 5 years in low-and middle-income countries where limited access to potable water, poor sanitation, deficient hygiene, and food product contamination are prevalent. Research on the changing etiology of AGE and associated risk factors in Latin America, including Colombia, is essential to understand the epidemiology of these infections. The primary objectives of this study were to describe etiology of moderate to severe AGE in children less than 5 years of age from Bucaramanga, Colombia, a middle-income country in Latin Ameri-can, and to identify the presence of emerging E. coli pathotypes. Methodology/Principal findings This was a prospective, matched for age, case-control study to assess the etiology of moderate to severe AGE in children less than 5 years of age in Bucaramanga, Colombia, South America. We tested for 24 pathogens using locally available diagnostic testing, including stool culture, polymerase chain reaction, microscopy and enzyme-linked immunoassay. Adjusted attributable fractions were calculated to assess the association between AGE and each pathogen in this study population. The study included 861 participants, 431 cases and 430 controls. Enteric pathogens were detected in 71% of cases and in 54% of controls (p = <0.001). Co-infection was identified in 28% of cases and in 14% of controls (p = <0.001). The adjusted attributable fraction showed that Norovirus GII explained 14% (95% CI: 10–18%) of AGE, followed by rotavirus 9.3% (6.4–12%), adenovirus 3% (1–4%), astrovirus 2.9% (0.6–5%), enterotoxigenic Escherichia coli (ETEC) 2.4% (0.4–4%), Cryptosporidium sp. 2% (0.5–4%), Campylobacter sp. 2% (0.2–4%), and Salmonella sp.1.9% (0.3 to 3.5%). Except for Cryptosporidium, all parasite infections were not associated with AGE. Three emergent diarrheagenic E. coli pathotypes were identified in cases (0.7%), including an enteroaggre-gative/enterotoxigenic E.coli (EAEC/ETEC), an enteroaggregative/enteropathogenic E.coli (EAEC/EPEC), and an emergent enteroinvasive E. coli with a rare O96:H19. No deaths were reported among cases or controls. Conclusions/Significance Norovirus and rotavirus explained the major proportion of moderate to severe AGE in this study. Higher proportion of infection in cases, in the form of single infections or co-infections, showed association with AGE. Three novel E. coli pathotypes were identified among cases in this geographic region.

Autor(es) UDES:
Farfán-García A.E., Arias-Guerrero M.Y., Sánchez-álvarez N.T.
Otros Autores:
Imdad A., Zhang C., Iqbal J., Hernández-Gamboa A.E., Slaughter J.C., Gómez-Duarte O.G.
Autor Principal:
Farfán-García A.E.
Áreas del conocimiento:
Public Health, Environmental and Occupational Health, Infectious Diseases
Acerca de la revista donde se publicó este artículo:

PLoS Neglected Tropical Diseases

Cuartil Q1
Ranking
2220
Tipo
Journal
ISSN
19352727
eISSN
19352735
Región
Northern America
País
United States
Volumen
14
Rango de páginas
1-20
Cobertura
2007-2021
Fecha de publicación:
2020-06-01
Tipo:
Article
Identificación:
SCOPUS_ID:85086456117
eID:
2-s2.0-85086456117
Nombre de la revista:
The Lancet Planetary Health
Título del artículo:

Associations of outdoor fine particulate air pollution and cardiovascular disease in 157 436 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study

Background: Most studies of long-term exposure to outdoor fine particulate matter (PM2·5) and cardiovascular disease are from high-income countries with relatively low PM2·5 concentrations. It is unclear whether risks are similar in low-income and middle-income countries (LMICs) and how outdoor PM2·5 contributes to the global burden of cardiovascular disease. In our analysis of the Prospective Urban and Rural Epidemiology (PURE) study, we aimed to investigate the association between long-term exposure to PM2·5 concentrations and cardiovascular disease in a large cohort of adults from 21 high-income, middle-income, and low-income countries. Methods: In this multinational, prospective cohort study, we studied 157 436 adults aged 35–70 years who were enrolled in the PURE study in countries with ambient PM2·5 estimates, for whom follow-up data were available. Cox proportional hazard frailty models were used to estimate the associations between long-term mean community outdoor PM2·5 concentrations and cardiovascular disease events (fatal and non-fatal), cardiovascular disease mortality, and other non-accidental mortality. Findings: Between Jan 1, 2003, and July 14, 2018, 157 436 adults from 747 communities in 21 high-income, middle-income, and low-income countries were enrolled and followed up, of whom 140 020 participants resided in LMICs. During a median follow-up period of 9·3 years (IQR 7·8–10·8; corresponding to 1·4 million person-years), we documented 9996 non-accidental deaths, of which 3219 were attributed to cardiovascular disease. 9152 (5·8%) of 157 436 participants had cardiovascular disease events (fatal and non-fatal incident cardiovascular disease), including 4083 myocardial infarctions and 4139 strokes. Mean 3-year PM2·5 at cohort baseline was 47·5 μg/m3 (range 6–140). In models adjusted for individual, household, and geographical factors, a 10 μg/m3 increase in PM2·5 was associated with increased risk for cardiovascular disease events (hazard ratio 1·05 [95% CI 1·03–1·07]), myocardial infarction (1·03 [1·00–1·05]), stroke (1·07 [1·04–1·10]), and cardiovascular disease mortality (1·03 [1·00–1·05]). Results were similar for LMICs and communities with high PM2·5 concentrations (>35 μg/m3). The population attributable fraction for PM2·5 in the PURE cohort was 13·9% (95% CI 8·8–18·6) for cardiovascular disease events, 8·4% (0·0–15·4) for myocardial infarction, 19·6% (13·0–25·8) for stroke, and 8·3% (0·0–15·2) for cardiovascular disease mortality. We identified no consistent associations between PM2·5 and risk for non-cardiovascular disease deaths. Interpretation: Long-term outdoor PM2·5 concentrations were associated with increased risks of cardiovascular disease in adults aged 35–70 years. Air pollution is an important global risk factor for cardiovascular disease and a need exists to reduce air pollution concentrations, especially in LMICs, where air pollution levels are highest. Funding: Full funding sources are listed at the end of the paper (see Acknowledgments).

Autor(es) UDES:
Lopez-Jaramillo P.
Otros Autores:
Hystad P., Larkin A., Rangarajan S., AlHabib K.F., Avezum Á., Calik K.B.T., Chifamba J., Dans A., Diaz R., du Plessis J.L., Gupta R., Iqbal R., Khatib R., Kelishadi R., Lanas F., Liu Z., Nair S., Poirier P., Rahman O., Rosengren A., Swidan H., Tse L.A., Wei L., Wielgosz A., Yeates K., Yusoff K., Zatoński T., Burnett R., Yusuf S., Brauer M.
Autor Principal:
Hystad P.
Áreas del conocimiento:
Medicine (miscellaneous), Health (social science), Health Policy, Public Health, Environmental and Occupational Health
Acerca de la revista donde se publicó este artículo:

The Lancet Planetary Health

Cuartil Q1
Ranking
484
Tipo
Journal
eISSN
25425196
Región
Western Europe
País
Netherlands
Volumen
4
Rango de páginas
e235-e245
Cobertura
2017-2021
Fecha de publicación:
2020-01-01
Tipo:
Article
Identificación:
SCOPUS_ID:85090815777
eID:
2-s2.0-85090815777
Nombre de la revista:
Revista de Biologia Tropical
Título del artículo:

Anatomical and histochemical alterations caused by powdery mildew on hydrangea mac-rophylla (Hydrangeaceae) leaves

Introduction: There are few studies concerning the morpho-anatomical and histochemical alterations caused by powdery mildew in H. macrophylla leaves in the scientific literature. Objective: To describe and analyze anatomical and histochemical aspects of this pathosystem. Methods: More than 90 leaves of H. macrophylla (both healthy and infected leaves by powdery mildew) were collected in the nursery El Jardín del Eden, Rionegro, Antioquia, Colombia. To carry out the identification of the mycopatho-gen, sections were stained with Lactophenol Blue, and contrasted with specialized taxonomic keys. Transverse fragments 1 cm thick were fixed in a mixture of formalin, alcohol, and acetic acid. These were subsequently dehydrated using an ethanol series, clarified in Xylene, and finally embedded in Paraplast plus® to obtain 5 µm sections. Schiff’s periodic acid reaction (PAS) was used to detect structural and reserve polysaccharides, Ruthenium Red for pectins, Ponseau S and Lacmoid for callose, ferric chloride for polyphenols, Sudan Black for lipids and Uvitex 2B-Hematoxylin for chitin. The sections were observed using a Nikon 80i eclipse® pho-ton microscope, with Uvitex 2B-Hematoxylin-stained sections examined by epifluorescence using a UV-2A filter. For the observation and description of the samples by scanning electron microscopy, healthy and infected leaves were fixed and dehydrated in 100 % methanol, critical point dried, and coated with gold. Results: H. macrophylla leaves are isobilateral and homobaric, with adaxial and abaxial epidermis of a single cellular layer. The palisade parenchyma consists of a layer of short cells, while the spongy parenchyma forms 6 to 7 cellular layers. All vascular bundles in the leaf blade are closed collaterals. Abundant idioblasts with raphides may be observed in the mesophyll, and starch is the main reserve carbohydrate present in the tissues. The leaves are hypostomatic and exhibit a paracytic pattern of superficial stomata which possess large substomatal cavities. The morphological data observed indicate that the mycopathogen is related to the genus Erysiphe. The epidermal cells affected by the pathogen exhibit thickened walls, granular cytoplasm, and papillae or cell wall appositions in the outer periclinal walls. With the deterioration of the epidermis, the underlying tissues are affected and become necrotic. Histochemical test indicate that infected plants thicken and reinforce their epidermal cell walls with primary wall materials; primarily cutin, pectins, and callose. When stained with Sudan Black, the presence of dark-colored agglomerates in the cytoplasm of epidermal cells may be related to plant defense mechanisms; and those observed in mesophilic cells to the disorganization of membrane systems. Polyphenols accumulate in the cytoplasm of infected epidermal cells. The fungal material present in epidermal tissues was clearly differenti-ated when stained with fluorochrome to detect chitin. Conclusions: Species of the genus Erysiphe are causative agents of powdery mildew in H. macrophylla. Necrosis of the epidermal cells is observed in response to the mycopathogen, possibly due to hypersensitive response.

Autor(es) UDES:
Rincón-Baron E.J.
Otros Autores:
Grisales-Echeverri C., Cuaran V.L., Nadya Lorena C.B.
Autor Principal:
Rincón-Baron E.J.
Áreas del conocimiento:
Agricultural and Biological Sciences (all)
Acerca de la revista donde se publicó este artículo:

Revista de Biologia Tropical

Cuartil Q2
Ranking
15276
Tipo
Journal
ISSN
00347744
eISSN
22152075
Región
Latin America
País
Costa Rica
Volumen
68
Rango de páginas
959-976
Cobertura
1969-2021
Fecha de publicación:
2022-12-01
Tipo:
Article
Número de artículo:
50
Identificación:
SCOPUS_ID:85131480050
eID:
2-s2.0-85131480050
Nombre de la revista:
Molecular Brain
Título del artículo:

Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation

Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting that it may be implicated in hippocampus-dependent long-term memory processing. Object recognition memory (ORM) allows animals to identify familiar items and is essential for remembering facts and events. In rodents, long-term ORM formation requires a functional hippocampus but the involvement of the MS in this process remains controversial. We found that training adult male Wistar rats in a long-term ORM-inducing learning task involving exposure to two different, but behaviorally equivalent novel stimuli objects increased hippocampal theta power, and that suppressing theta via optogenetic MS inactivation caused amnesia. Importantly, the amnesia was specific to the object the animals were exploring when the MS was inactivated. Taken together, our results indicate that the MS is necessary for long-term ORM formation and suggest that hippocampal theta activity is causally linked to this process.

Autor(es) UDES:
Conde-Ocazionez S.
Otros Autores:
Gonzalez M.C., Radiske A., Rossato J.I., Bevilaqua L.R.M., Cammarota M.
Autor Principal:
Gonzalez M.C.
Áreas del conocimiento:
Molecular Biology, Cellular and Molecular Neuroscience
Acerca de la revista donde se publicó este artículo:

Molecular Brain

Cuartil Q2
Ranking
2720
Tipo
Journal
eISSN
17566606
Región
Western Europe
País
United Kingdom
Volumen
15
Cobertura
2008-2021
Fecha de publicación:
2022-12-01
Tipo:
Erratum
Número de artículo:
9355
Identificación:
SCOPUS_ID:85131430080
eID:
2-s2.0-85131430080
Nombre de la revista:
Scientific Reports
Título del artículo:

Author Correction: Contributing factors for acute stress in healthcare workers caring for COVID-19 patients in Argentina, Chile, Colombia, and Ecuador (Scientific Reports, (2022), 12, 1, (8496), 10.1038/s41598-022-12626-2)

The Funding section in the original version of this Article was incomplete. \"This study was supported by PROMETEO/2021/061 grant (Generalitat Valenciana, 2021). J.M.D., R.P., P.S., I.C., E.G.E., M.G., and J.J.M. were supported by The European Cooperation in Science and Technology, COST [Grant Number CA19113].\" now reads: \"This study was supported by Generalitat Valenciana, 2021. CONV. UMH-GVA REF. SOLCIF 2020/0005. (Cód. Sub. 11-134-4-2021-0068). J.M.D., R.P., P.S., I.C., E.G.E., M.G., and J.J.M. were supported by The European Cooperation in Science and Technology, COST [Grant Number CA19113].\" The original Article has been corrected.

Autor(es) UDES:
Serpa P.
Otros Autores:
Martin-Delgado J., Poblete R., Mula A., Carrillo I., Fernández C., Ripoll M.A.V., Loudet C., Jorro F., Elorrio E.G., Guilabert M., Mira J.J.
Autor Principal:
Martin-Delgado J.
Áreas del conocimiento:
Multidisciplinary
Acerca de la revista donde se publicó este artículo:

Scientific Reports

Cuartil Q1
Ranking
4084
Tipo
Journal
eISSN
20452322
Región
Western Europe
País
United Kingdom
Volumen
12
Cobertura
2011-2021
Fecha de publicación:
2022-12-01
Tipo:
Data Paper
Número de artículo:
57
Identificación:
SCOPUS_ID:85124778304
eID:
2-s2.0-85124778304
Nombre de la revista:
Scientific Data
Título del artículo:

A database of common vampire bat reports

The common vampire bat (Desmodus rotundus) is a sanguivorous (i.e., blood-eating) bat species distributed in the Americas from northern Mexico southwards to central Chile and Argentina. Desmodus rotundus is one of only three mammal species known to feed exclusively on blood, mainly from domestic mammals, although large wildlife and occasionally humans can also serve as a food source. Blood feeding makes D. rotundus an effective transmissor of pathogens to its prey. Consequently, this species is a common target of culling efforts by various individuals and organizations. Nevertheless, little is known about the historical distribution of D. rotundus. Detailed occurrence data are critical for the accurate assessment of past and current distributions of D. rotundus as part of ecological, biogeographical, and epidemiological research. This article presents a dataset of D. rotundus historical occurrence reports, including >39,000 locality reports across the Americas to facilitate the development of spatiotemporal studies of the species. Data are available at https://doi.org/10.6084/m9.figshare.15025296.

Autor(es) UDES:
Gutiérrez J.D.
Otros Autores:
Van de Vuurst P., Díaz M.M., Rodríguez-San Pedro A., Allendes J.L., Brown N., Zarza H., de Oliveira S.V., Cárdenas-Canales E., Barquez R.M., Escobar L.E.
Autor Principal:
Van de Vuurst P.
Áreas del conocimiento:
Statistics and Probability, Information Systems, Education, Computer Science Applications, Statistics, Probability and Uncertainty, Library and Information Sciences
Acerca de la revista donde se publicó este artículo:

Scientific Data

Cuartil Q1
Ranking
858
Tipo
Journal
eISSN
20524463
Región
Western Europe
País
United Kingdom
Volumen
9
Cobertura
2014-2021
Fecha de publicación:
2022-09-01
Tipo:
Article
Número de artículo:
113430
Identificación:
SCOPUS_ID:85129707807
eID:
2-s2.0-85129707807
Nombre de la revista:
Environmental Research
Título del artículo:

Personal and household PM2.5 and black carbon exposure measures and respiratory symptoms in 8 low- and middle-income countries

Background: Household air pollution (HAP) from cooking with solid fuels has been associated with adverse respiratory effects, but most studies use surveys of fuel use to define HAP exposure, rather than on actual air pollution exposure measurements. Objective: To examine associations between household and personal fine particulate matter (PM2.5) and black carbon (BC) measures and respiratory symptoms. Methods: As part of the Prospective Urban and Rural Epidemiology Air Pollution study, we analyzed 48-h household and personal PM2.5 and BC measurements for 870 individuals using different cooking fuels from 62 communities in 8 countries (Bangladesh, Chile, China, Colombia, India, Pakistan, Tanzania, and Zimbabwe). Self-reported respiratory symptoms were collected after monitoring. Associations between PM2.5 and BC exposures and respiratory symptoms were examined using logistic regression models, controlling for individual, household, and community covariates. Results: The median (interquartile range) of household and personal PM2.5 was 73.5 (119.1) and 65.3 (91.5) μg/m3, and for household and personal BC was 3.4 (8.3) and 2.5 (4.9) x10−5 m−1, respectively. We observed associations between household PM2.5 and wheeze (OR: 1.25; 95%CI: 1.07, 1.46), cough (OR: 1.22; 95%CI: 1.06, 1.39), and sputum (OR: 1.26; 95%CI: 1.10, 1.44), as well as exposure to household BC and wheeze (OR: 1.20; 95%CI: 1.03, 1.39) and sputum (OR: 1.20; 95%CI: 1.05, 1.36), per IQR increase. We observed associations between personal PM2.5 and wheeze (OR: 1.23; 95%CI: 1.00, 1.50) and sputum (OR: 1.19; 95%CI: 1.00, 1.41). For household PM2.5 and BC, associations were generally stronger for females compared to males. Models using an indicator variable of solid versus clean fuels resulted in larger OR estimates with less precision. Conclusions: We used measurements of household and personal air pollution for individuals using different cooking fuels and documented strong associations with respiratory symptoms.

Autor(es) UDES:
Lopez-Jaramillo P.
Otros Autores:
Wang Y., Shupler M., Birch A., Chu Y.L., Jeronimo M., Rangarajan S., Mustaha M., Heenan L., Seron P., Saavedra N., Oliveros M.J., Camacho P.A., Otero J., Perez-Mayorga M., Yeates K., West N., Ncube T., Ncube B., Chifamba J., Yusuf R., Khan A., Liu Z., Cheng X., Wei L., Tse L.A., Mohan D., Kumar P., Gupta R., Mohan I., Jayachitra K.G., Mony P.K., Rammohan K., Nair S., Lakshmi P.V.M., Sagar V., Khawaja R., Iqbal R., Kazmi K., Yusuf S., Brauer M., Hystad P.
Autor Principal:
Wang Y.
Áreas del conocimiento:
Biochemistry, Environmental Science (all)
Acerca de la revista donde se publicó este artículo:

Environmental Research

Tipo
Journal
ISSN
00139351
eISSN
10960953
Volumen
212
Fecha de publicación:
2022-08-31
Tipo:
Article
Identificación:
SCOPUS_ID:85137193343
eID:
2-s2.0-85137193343
Nombre de la revista:
Iatreia
Título del artículo:

Mecanismos de acción de péptidos antibacterianos Ib-M contra Escherichia coli. Un estudio estructural y proteómico. Avances de resultados

Autor(es) UDES:
Farfán-García A.E., Flórez-Castillo J.M.
Otros Autores:
Restrepo-Pineda E.D.
Autor Principal:
Farfán-García A.E.
Áreas del conocimiento:
Medicine (all)
Acerca de la revista donde se publicó este artículo:

Iatreia

Cuartil Q4
Ranking
23685
Tipo
Journal
ISSN
01210793
Región
Latin America
País
Colombia
Volumen
35
Rango de páginas
S5-S7
Cobertura
1988-2021
Fecha de publicación:
2022-08-15
Tipo:
Article
Identificación:
SCOPUS_ID:85132831794
eID:
2-s2.0-85132831794
Nombre de la revista:
International Journal of Hydrogen Energy
Título del artículo:

Towards the Hydrogen Economy in Paraguay: Green hydrogen production potential and end-uses

This study was conducted to estimate the potential for green H2 in Paraguay. A total production potential of 22.5 × 106 tons/year was obtained with a main contribution (93.34%) from solar photovoltaic. The greatest potential for producing H2 from solar and wind resources is in the Western region, and from hydro resources is in the Eastern region of the country. Two end-uses of green H2 were assessed: (1) automotive transportation, replacing gasoline and diesel; and (2) residential energy, replacing firewood and LPG for cooking in households across the country. In 16 of the 17 departments, green H2 is able to replace the overall consumption of gasoline and diesel, as well as firewood and LPG. Finally, energy service cost (mobility), environmental aspects and CO2 emissions were considered for three urban mobility technologies for the Metropolitan Area of Asunción. Results show that the mobility cost of fuel cell hybrid electric buses is still very high in comparison to diesel buses and battery electric buses. However, when a longer driving range is required, fuel cell hybrid electric buses could become a viable alternative in the long term. From an environmental point of view, green H2 used in fuel cell hybrid electric buses has the potential to save about 96% of CO2 emissions in comparison to diesel buses. It is concluded that the estimated green H2 production potential favors the incorporation of the Hydrogen Economy in Paraguay.

Autor(es) UDES:
Posso F.
Otros Autores:
Galeano M., Baranda C., Franco D., Rincón A., Zambrano J., Cavaliero C., Lópes D.
Autor Principal:
Posso F.
Áreas del conocimiento:
Renewable Energy, Sustainability and the Environment, Fuel Technology, Condensed Matter Physics, Energy Engineering and Power Technology
Acerca de la revista donde se publicó este artículo:

International Journal of Hydrogen Energy

Cuartil Q1
Ranking
3056
Tipo
Journal
ISSN
03603199
Región
Western Europe
País
United Kingdom
Volumen
47
Rango de páginas
30027-30049
Cobertura
1976-2021
Fecha de publicación:
2022-08-09
Tipo:
Article
Número de artículo:
e13801
Identificación:
SCOPUS_ID:85135895592
eID:
2-s2.0-85135895592
Nombre de la revista:
PeerJ
Título del artículo:

The use of synthetic agonists of quorum sensing N- acyl homoserine lactone pathway improves the bioleaching ability in Acidithiobacillus and Pseudomonas bacteria

Metal solubilization from discarded electrical material and electronic devices (e-waste) using the bioleaching capabilities of bacterial cells is highly effective. However, gaps in understanding about the microbiological processes involved in the bioleaching reaction leads to less efficient metal solubilization in large-scale e-waste processing. In this study, bacterial species belonging to the genera Acidithiobacillus and Pseudomonas were used to leach copper and gold from discarded printed circuit boards (PCB). Through modulation of the cell-to-cell communication system in these bacteria, phenotypic traits directly involved in the bioleaching reaction were regulated in order to improve the metal solubilization. Addition of the long chain synthetic autoinducer molecule N-acyl homoserine lactone (AHL) of the quorum sensing pathway to the bioleaching reaction resulted in a significant enhancement of metal extraction from PCB. Factors such as: cell attachment to PCB, biofilm formation and hydrogen cyanide (HCN) production were regulated by the quorum sensing system and could be directly related to the improvement of metal bioleaching. Bioleaching reactions using bacterial quorum sensing modulation could represent a valuable tool in overcoming limitations at the industrial level imposed by microbiological traits that lead to inefficient metal bioleaching from e-waste.

Autor(es) UDES:
Caicedo J.C., Orlandoni G.
Otros Autores:
Villamizar S.
Autor Principal:
Caicedo J.C.
Áreas del conocimiento:
Neuroscience (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all)
Acerca de la revista donde se publicó este artículo:

PeerJ

Cuartil Q1
Ranking
6102
Tipo
Journal
eISSN
21678359
Región
Northern America
País
United States
Volumen
10
Cobertura
2013-2021
Fecha de publicación:
2022-08-07
Tipo:
Article
Identificación:
SCOPUS_ID:85130630734
eID:
2-s2.0-85130630734
Nombre de la revista:
European Heart Journal
Título del artículo:

Risk factors, cardiovascular disease, and mortality in South America: a PURE substudy

Aims: In a multinational South American cohort, we examined variations in CVD incidence and mortality rates between subpopulations stratified by country, by sex and by urban or rural location. We also examined the contributions of 12 modifiable risk factors to CVD development and to death. Methods and results: This prospective cohort study included 24 718 participants from 51 urban and 49 rural communities in Argentina, Brazil, Chile, and Colombia. The mean follow-up was 10.3 years. The incidence of CVD and mortality rates were calculated for the overall cohort and in subpopulations. Hazard ratios and population attributable fractions (PAFs) for CVD and for death were examined for 12 common modifiable risk factors, grouped as metabolic (hypertension, diabetes, abdominal obesity, and high non-HDL cholesterol), behavioural (tobacco, alcohol, diet quality, and physical activity), and others (education, household air pollution, strength, and depression). Leading causes of death were CVD (31.1%), cancer (30.6%), and respiratory diseases (8.6%). The incidence of CVD (per 1000 person-years) only modestly varied between countries, with the highest incidence in Brazil (3.86) and the lowest in Argentina (3.07). There was a greater variation in mortality rates (per 1000 person-years) between countries, with the highest in Argentina (5.98) and the lowest in Chile (4.07). Men had a higher incidence of CVD (4.48 vs. 2.60 per 1000 person-years) and a higher mortality rate (6.33 vs. 3.96 per 1000 person-years) compared with women. Deaths were higher in rural compared to urban areas. Approximately 72% of the PAF for CVD and 69% of the PAF for deaths were attributable to 12 modifiable risk factors. For CVD, largest PAFs were due to hypertension (18.7%), abdominal obesity (15.4%), tobacco use (13.5%), low strength (5.6%), and diabetes (5.3%). For death, the largest PAFs were from tobacco use (14.4%), hypertension (12.0%), low education (10.5%), abdominal obesity (9.7%), and diabetes (5.5%). Conclusions: Cardiovascular disease, cancer, and respiratory diseases account for over two-thirds of deaths in South America. Men have consistently higher CVD and mortality rates than women. A large proportion of CVD and premature deaths could be averted by controlling metabolic risk factors and tobacco use, which are common leading risk factors for both outcomes in the region.

Autor(es) UDES:
Lopez-Jaramillo P., Lopez-Lopez J.P.
Otros Autores:
Joseph P., Lanas F., Avezum A., Diaz R., Camacho P.A., Seron P., Oliveira G., Orlandini A., Rangarajan S., Islam S., Yusuf S.
Autor Principal:
Lopez-Jaramillo P.
Áreas del conocimiento:
Cardiology and Cardiovascular Medicine
Acerca de la revista donde se publicó este artículo:

European Heart Journal

Tipo
Journal
ISSN
0195668X
eISSN
15229645
Volumen
43
Rango de páginas
2841-2851
Fecha de publicación:
2022-08-01
Tipo:
Article
Número de artículo:
3149
Identificación:
SCOPUS_ID:85137114737
eID:
2-s2.0-85137114737
Nombre de la revista:
Polymers
Título del artículo:

Immobilization Systems of Antimicrobial Peptide Ib−M1 in Polymeric Nanoparticles Based on Alginate and Chitosan

The development of new strategies to reduce the use of traditional antibiotics has been a topic of global interest due to the resistance generated by multiresistant microorganisms, including Escherichia coli, as etiological agents of various diseases. Antimicrobial peptides are presented as an alternative for the treatment of infectious diseases caused by this type of microorganism. The Ib−M1 peptide meets the requirements to be used as an antimicrobial compound. However, it is necessary to use strategies that generate protection and resist the conditions encountered in a biological system. Therefore, in this study, we synthesized alginate and chitosan nanoparticles (Alg−Chi NPs) using the ionic gelation technique, which allows for the crosslinking of polymeric chains arranged in nanostructures by intermolecular interactions that can be either covalent or non-covalent. Such interactions can be achieved through the use of crosslinking agents that facilitate this binding. This technique allows for immobilization of the Ib−M1 peptide to form an Ib−M1/Alg−Chi bioconjugate. SEM, DLS, and FT-IR were used to determine the structural features of the nanoparticles. We evaluated the biological activity against E. coli ATCC 25922 and Vero mammalian cells, as well as the stability at various temperatures, pH, and proteases, of Ib−M1 and Ib−M1/Alg-Chi. The results showed agglomerates of nanoparticles with average sizes of 150 nm; an MIC of 12.5 µM, which was maintained in the bioconjugate; and cytotoxicity values close to 40%. Stability was maintained against pH and temperature; in proteases, it was only evidenced against pepsin in Ib−M1/Alg-Chi. The results are promising with respect to the use of Ib−M1 and Ib−M1/Alg−Chi as possible antimicrobial agents.

Autor(es) UDES:
Osorio-Alvarado C.E., Ropero-Vega J.L., Farfán-García A.E., Flórez-Castillo J.M.
Autor Principal:
Osorio-Alvarado C.E.
Áreas del conocimiento:
Chemistry (all), Polymers and Plastics
Acerca de la revista donde se publicó este artículo:

Polymers

Cuartil Q1
Ranking
6545
Tipo
Journal
eISSN
20734360
Región
Western Europe
País
Switzerland
Volumen
14
Cobertura
1969, 2009-2021
Image
Servicios
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